Temporal risk changes of heart failure among childhood cancer survivors
January 19, 2019
From the 1940s to present day cancer survival rates have increased significantly, from 20% to between 70% and 80%. Often times, however, pediatric cancer treatments can leave detrimental long-term health conditions for childhood cancer survivors. For these survivors, it is expected that nearly 75% will develop some chronic health condition at a later point in life.
The Dutch Childhood Oncology Group-Long Term Effects After Childhood cancer (DCOG-LATER) is a group consisting of 6,165 childhood cancer survivors who were diagnosed from 1963 and 2002. From this organization, information on cancer history and treatments were gathered. As determined from this data, 116 survivors out of 5,845 surveyed had developed heart failure at a median age of 27 years, averaging 20 years after follow-up. In this multivariable experiment, it was determined that larger doses of mitoxantrone as well cyclophosphamide led to larger risks of heart failure than those who were exposed to lower quantities.